Endocrine Abstracts

Male problems such as oligospermia, azoospermia among others, affect around 30% of infertile couples. Male fecundity relies on the production of large numbers of spermatozoa which is dependent on the number of Sertoli cells. Activin and related TGFβ family ligands regulate testicular development and function. Follistatin Like-3 (FSTL3) is a glycoprotein that binds and inhibits activin. FSTL3 deletion in mice leads to increased adult testicular size with concurrent increas...

Male problems such as oligospermia, azoospermia among others, affect around 30% of infertile couples. Male fecundity relies on the production of large numbers of spermatozoa which is dependent on the number of Sertoli cells. Activin and related TGFβ family ligands regulate testicular development and function. Follistatin Like-3 (FSTL3) is a glycoprotein that binds and inhibits activin. FSTL3 deletion in mice leads to increased adult testicular size with concurrent increas...

This is a case of an adult female who presented with 1 year history of palpitations, heat intolerance, easy fatigability, hyperdefecation and proptosis. She was admitted to this institution due to 3 month history of nausea, vomiting, abdominal pain, flank pain and generalized weakness. During admission, she was diagnosed with hyperthyroidism supported by laboratory findings of suppressed thyroid stimulating hormone and elevated free thyroxine levels and was then treated with m...

Background: Type 2 DM and chronic renal disease CKD are conditions associated with severe hypertension, loss of the blood pressure circadian rhythm (CR) and sympathetic nervous system (SNS) hyperactivity, suggesting a deficient dopaminergic modulation that could be reversed with dopamine agonists such as bromocriptine (BEC).Objective: The objective of this study was to evaluate the effect of bromocriptine in the blood pressure CR in patients with type 2 ...

Introduction: Adrenal Cushing’s syndrome during pregnancy is rare, and few cases have been reported. It is infrequent to identify pregnant women with adenomas that have cortisol and androgen co-secretion. The diagnosis and treatment of excess cortisol during pregnancy is challenging when the patient does not want a pregnancy interruption.Case Report: 38-year-old woman with arterial hypertension for four years. During her working days, she remained u...

GH deficiency (GHD) and excess of glucocorticoids are associated with increased risk of fragility fractures. Most adult GHD patients have other pituitary deficiencies, but it is unclear whether these deficiencies or their overreplacement therapies may influence the bone disease occurring in GHD. The aim of this study was to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid replacement therapy in hypopituitary males with GHD. We studied ...

Background: PWS is a rare neurodevelopmental genetic disorder characterized by hyperphagia, obesity, hormonal deficiencies, and problem behaviors for which there are no approved treatment. DCCR administration (100-525 mg/day) up to 52 weeks in participants with PWS improved hyperphagia, behavior, body composition and metabolic markers.Objective: The objective of this study was to compare changes in hyperphagia (using Hyperphagia Questionnaire for Clinica...

Background: Prader-Willi syndrome (PWS), a rare genetic neurobehavioral-metabolic condition, is characterized by hyperphagia, accumulation of excess fat, hypotonia, and behavioral/psychological complications. There are no currently approved medications to treat hyperphagia in patients with PWS; DCCR is under development as a treatment for PWS.Objectives and Methods: The objective was to evaluate long-term safety of DCCR in individuals with PWS. 125 parti...